30mg X 60 capules-98% Pure Spermidine 2months Supply 🇦🇺

What is spermidine?

Spermidine is a naturally occurring polyamine found in all living organisms. It plays an important role in numerous cellular functions, such as maintaining DNA stability, copying DNA into RNA, and preventing cell death. In addition, spermidine has been found to reduce the development of many age-related health conditions, including cardiovascular diseases.

During the aging process, the levels of spermidine decrease, resulting in the development of age-related conditions. Therefore, maintaining optimal levels of spermidine throughout life has been suggested to reduce the development of diseases and increase longevity.

How does spermidine work?

One of the most critical roles spermidine plays in the anti-aging process is through the regulation of autophagy. Autophagy is the cell's way of getting rid of damaged cellular components, and this ability decreases as we age. The supplementation of spermidine has been shown to increase autophagy in the liver, heart, and muscle tissue and is associated with prolonging the lifespan of these cells.

Excessive inflammation has been shown to enhance the aging process and plays an important role in the development of many age-associated diseases. However, spermidine has an anti-inflammatory effect by eliminating reactive oxygen species, decreasing the migration of immune cells into tissues, and reducing the production of pro-inflammatory molecules by the body. By suppressing inflammation, spermidine can prevent age-related diseases.

The deficiency of spermidine can reduce cell growth and the ability of cells to mature into more specialized cells. Spermidine can also prevent cell death. Overall, spermidine regulates the cellular lifecycle by enhancing functions correlated with increasing the lifespan of cells.

Finally, spermidine also works by inhibiting the acetylation of histones and maintaining normal lipid metabolism. In addition, spermidine can protect cellular DNA from oxidative attacks.

All these actions of spermidine are thought to work together to enhance longevity and promote a healthy life.

How can you increase your spermidine levels?

Spermidine levels can be increased by increasing foods rich in spermidine, spermidine supplements and spermidine production by bacteria within the intestines. The bacteria in the intestines synthesize a small amount of spermidine, which is unlikely to provide the daily recommended amounts. The two most reliable ways to increase your spermidine are through diet and supplements, but only dietary spermidine has been shown in studies to increase longevity.

Foods

The consumption of foods high in spermidine provides complete spectrum supplementation, as they provide additional polyamines the body can use to synthesize spermidine. The foods highest in spermidine include:

• Wheat and whole grains
• Broccoli and cauliflower
• Mushrooms
• Peas
• Mangos
• Soybeans and soy products
• Chicken

Supplements

Limited data is available on the benefits of supplements containing spermidine and their overall effects on longevity and health. In addition, there are two different kinds of supplements. Some supplements contain synthetic spermidine while others contain spermidine from wheat germ extract. Which is best?

Synthetic spermidine supplements are typically cheaper and only contain spermidine. However, those from wheat germ extract often contain additional polyamines to help support healthy spermidine levels, but they can be more expensive. Although using those from wheat germ extract is recommended, there is little scientific data to support their use. In addition, it is always recommended to pick supplements that have been third-party tested.

Spermidine benefits reviewed

The greatest benefit of spermidine is its ability to reduce age-related diseases, which is thought to increase longevity and result in an anti-aging effect. The clinical benefits of spermidine have been researched and are attributed to many of the factors discussed above in how spermidine works.

Cardiovascular benefits

Coronary artery disease (CAD) is the leading cause of death due to the development of atherosclerotic plaques, which narrow arteries and impair blood flow to the heart. Spermidine has been shown to decrease the development of atherosclerosis in mice by decreasing inflammation and improving cell (mitochondria) functioning. Additionally, spermidine can reduce blood clot formation (platelet aggregation) and improve the normal dilatory effect of the cells lining blood vessels.

Spermidine has been shown to reduce blood pressure, a known risk factor for CAD. The autophagy effects of spermidine help to prevent detrimental remodeling of blood vessels. Additionally, autophagy in heart tissue helps to prevent the formation of heart failure. In addition, spermidine helps to improve energy usage and reduce cell death in the heart, which is protective against heart failure.

Prevents neurologic diseases

Neurologic diseases such as Alzheimer's and Parkinson's are due to the selective loss of neurons within specific brain areas. Through stimulation of autophagy, spermidine protects against nerve damage in these areas of the brain, preventing the development of neurologic diseases. Spermidine has been shown to help reduce the cognitive, memory, and functional impairments associated with aging.

Decreases blood sugar levels

Diabetes is characterized by high blood sugar levels, as the body cannot use natural insulin to lower sugar levels. Spermidine has been shown to improve the body's ability to use insulin and decrease blood sugar levels. In addition, spermidine has been shown to improve the use of glucose by muscles and prevent long-term complications of diabetes. However, it should be noted that spermidine supplementation is not an alternative to diabetic medications.

Induces autophagy

Spermidine has been shown to reduce obesity in a study involving mice. It is thought that spermidine increases autophagy in fat cells, which works against the development of obesity. There is also evidence that spermidine can inhibit genes that increase susceptibility to obesity.

Increases bone strength

Spermidine has been found to increase bone strength and prevent bone loss, two factors that make it beneficial in preventing osteoporosis. Additionally, spermidine can prevent age-related loss of skeletal muscle and improve skeletal muscle functioning, a beneficial feature in maintaining a long, healthy life.

Osteoarthritis can also be prevented by a diet high in spermidine. Its actions as an antioxidant, anti-inflammatory, and autophagy activator are thought to preserve normal cartilage and help to degrade arthritic cartilage.

Anti-inflammatory effects

The use of spermidine has been shown to reduce the severity of inflammatory bowel disease in mice through its anti-inflammatory effects. Its use has also been shown to prevent the loss of certain memory cells of the immune system, resulting in an increased ability to fight viruses such as influenza. Overall, spermidine is thought to boost the immune system against outside threats while preventing the immune system from attacking normal cells, as seen in inflammatory bowel disease.

Can spermidine cause side effects?

No. Spermidine is a natural component found in many foods, including vegetables and whole grains. Additionally, it is normally found in the body and serves several vital roles in the functioning of cells. Therefore, it is well-tolerated and safe to take in both the supplement form and through dietary food supplementation.

The only recommendation when selecting spermidine supplements is to use those that extract spermidine from food sources. These supplements have the best safety profile and are thought to be most likely to produce the beneficial effects of foods high in spermidine.